The tracer kinetic model is for timeâ€resolved NMR spectra of HP 129Xe in the human brain to estimate the transfer rate of HP 129Xe from cerebral blood to gray matter that depends on a tracer transfer constant for a known mean transit time and cerebral blood volume for gray matter.
They believe this model will enable further studies to determine regional 129Xe tracer transfer constants with a focus of gaining insight into the pathophysiology of the blood brain barrier.
In addition, in light of the passive nature of the xenon tracer, it could serve as a crossâ€reference for studies involving oxygen, water or glucose uptake, which are driven by metabolism and/or electrolytic balance.
Article
(Magnetic Resonance in Medicine) M R Rao, G Norquay, N J Stewart, J M Wild.
