Dr Jen-Yu (Amy) Chang
BSc (Pharm), MSc (ClinPharm), PhD
School of Medicine and Population Health
Research Fellow in Statistics
Full contact details
School of Medicine and Population Health
Regent Court (ScHARR)
30 Regent Street
Sheffield
S1 4DA
- Profile
-
I joined SCHARR as a staff member after completing my PhD here, where I specialised in treatment sequences in health economic evaluations and the incorporation of advanced causal inference methods. My research focuses on applying these techniques—such as Target Trial Emulation and g-methods—to generate real-world evidence on the comparative effectiveness of treatment sequences using secondary databases. My research addresses the challenges in evaluating treatment sequences within HTA due to the lack of clinical evidence, as trials typically do not compare treatment sequences. Importantly, merging evidence from different treatment lines of trials requires making population exchangeability assumptions, which may not always hold.
Prior to my PhD, I obtained a BSc and an MSc in Pharmacy/Clinical Pharmacy, during which I developed a cost-effectiveness model that informed the national reimbursement of a pharmacist-led anticoagulation service in Taiwan. I then worked in an academic role with consultancy responsibilities, supporting local HTA submissions for pharmaceutical companies by adapting oncology economic models and generating local evidence using national claims data. Alongside this core responsibility, I contributed to the construction of the Taiwan EQ-5D-5L tariff model and healthcare utilisation and pharmacoepidemiology studies using Taiwan national health insurance claims and US NHIS survey data. Additionally, I worked as a pharmacist from time to time.
- Research interests
-
My current research interests lie in health economic modelling and related research methodologies with an emphasis on the comparison of treatment sequences. From a wider perspective, I am interested in applying causal inference methods and using real-world data to inform economic evaluation.
I am an active learner and keen on having exposure to innovative analytical methods and interdisciplinary research.
- Publications
-
Show: Featured publications All publications
Featured publications
This person does not have any publications available.
All publications
Journal articles
- . PharmacoEconomics, 42(5), 487-506.
- . The European Journal of Health Economics, 25(6), 1041-1055.
- . Quality of Life Research, 30(7), 2097-2108.
- . Journal of Women's Health, 28(7), 965-975.
- . PLoS ONE, 13(12).
- . International Journal for Quality in Health Care, 29(6), 817-825.
Conference proceedings papers
- . Value in Health, Vol. 27(12) (pp S450-S450)
- . Value in Health, Vol. 25(12 Suppl) (pp S461). Vienna, Austria, 6 November 2022 - 6 November 2022.
- . Quality of Life Research, Vol. 28(S1) (pp 1-190)
- The role of context and label in participants' quantitative interpretation of common quality of life PROM response options. QUALITY OF LIFE RESEARCH, Vol. 28 (pp S136-S137)
- . Value in Health, Vol. 21 (pp S91-S91)
- . Value in Health, Vol. 21 (pp S89-S89)
- . Value in Health, Vol. 20(9) (pp A797-A797)
- . Value in Health, Vol. 20(9) (pp A463-A464)
- . Value in Health, Vol. 19(7) (pp A612-A613)
- . PharmacoEconomics, 42(5), 487-506.
- Research group
-
SCHARR-TAG:
PhD Supervisors:
Professor Jim Chilcott
- Teaching interests
-
I currently support the survival analysis component in R for HAR6178: Further Statistical Methods for Health Economic Analysis. I've led tutorials for an MBChB module on medical research design and the critical appraisal of RCTs and systematic reviews. I’ve also served as a peer mentor for new PhD students.